Study Overview

Purpose of the Study

In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI).

Study Details

This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).

What to Expect

You will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, you will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.

The baseline visits and evaluation visits last approximately 4 hours and will involve an MRI scan and cognitive testing. During the weeks of rTMS study visits you will undergo rTMS every day: Monday through Friday. These study visit days will last approximately 2 hours.

Contact Information

If you are interested in learning more about this research study, please contact Anna Du (andu@mgh.harvard.edu)